Organic Slant

  • Home
  • Shop
  • About
  • Facebook
  • Twitter
  • YouTube
  • Articles
  • Videos
  • Cartoons
  • Music
  • Links
  • Cancer
  • Environment
  • GMO’s
  • Health
  • Monsanto
  • Organic Foods
  • Super Foods
  • Fukushima
You are here: Home / Health / Canola Oil Linked To Worsened Memory And Learning Ability In Alzheimer’s

Canola Oil Linked To Worsened Memory And Learning Ability In Alzheimer’s

December 8, 2017 by Captain Organic Planet

canola-oil-linked-to-worsened-memory-and-learning-ability-in-alzheimers-1024w

Canola oil is one of the most widely consumed vegetable oils in the world, yet surprisingly little is known about its effects on health. Now, a new study published online December 7 in the journal Scientific Reports by researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) associates the consumption of canola oil in the diet with worsened memory, worsened learning ability and weight gain in mice which model Alzheimer’s disease. The study is the first to suggest that canola oil is more harmful than healthful for the brain.

“Canola oil is appealing because it is less expensive than other vegetable oils, and it is advertised as being healthy,” explained Domenico Praticò, MD, Professor in the Departments of Pharmacology and Microbiology and Director of the Alzheimer’s Center at LKSOM, as well as senior investigator on the study. “Very few studies, however, have examined that claim, especially in terms of the brain.”

Curious about how canola oil affects brain function, Dr. Praticò and Elisabetta Lauretti, a graduate student in Dr. Pratico’s laboratory at LKSOM and co-author on the new study, focused their work on memory impairment and the formation of amyloid plaques and neurofibrillary tangles in an Alzheimer’s disease mouse model. Amyloid plaques and phosphorylated tau, which is responsible for the formation of tau neurofibrillary tangles, contribute to neuronal dysfunction and degeneration and memory loss in Alzheimer’s disease. The animal model was designed to recapitulate Alzheimer’s in humans, progressing from an asymptomatic phase in early life to full-blown disease in aged animals.

Dr. Praticò and Lauretti had previously used the same mouse model in an investigation of olive oil, the results of which were published earlier in 2017. In that study, they found that Alzheimer mice fed a diet enriched with extra-virgin olive oil had reduced levels of amyloid plaques and phosphorylated tau and experienced memory improvement. For their latest work, they wanted to determine whether canola oil is similarly beneficial for the brain.

The researchers started by dividing the mice into two groups at six months of age, before the animals developed signs of Alzheimer’s disease. One group was fed a normal diet, while the other was fed a diet supplemented with the equivalent of about two tablespoons of canola oil daily.

The researchers then assessed the animals at 12 months. One of the first differences observed was in body weight — animals on the canola oil-enriched diet weighed significantly more than mice on the regular diet. Maze tests to assess working memory, short-term memory, and learning ability uncovered additional differences. Most significantly, mice that had consumed canola oil over a period of six months suffered impairments in working memory.

Examination of brain tissue from the two groups of mice revealed that canola oil-treated animals had greatly reduced levels of amyloid beta 1-40. Amyloid beta 1-40 is the more soluble form of the amyloid beta proteins. It generally is considered to serve a beneficial role in the brain and acts as a buffer for the more harmful insoluble form, amyloid beta 1-42.

As a result of decreased amyloid beta 1-40, animals on the canola oil diet further showed increased formation of amyloid plaques in the brain, with neurons engulfed in amyloid beta 1-42. The damage was accompanied by a significant decrease in the number of contacts between neurons, indicative of extensive synapse injury. Synapses, the areas where neurons come into contact with one another, play a central role in memory formation and retrieval.

“Amyloid beta 1-40 neutralizes the actions of amyloid 1-42, which means that a decrease in 1-40, like the one observed in our study, leaves 1-42 unchecked,” Dr. Praticò explained. “In our model, this change in ratio resulted in considerable neuronal damage, decreased neural contacts, and memory impairment.”

The findings suggest that long-term consumption of canola oil is not beneficial to brain health. “Even though canola oil is a vegetable oil, we need to be careful before we say that it is healthy,” Dr. Praticò said. “Based on the evidence from this study, canola oil should not be thought of as being equivalent to oils with proven health benefits.”

The next step is to carry out a study of shorter duration to determine the minimum extent of exposure necessary to produce observable changes in the ratio of amyloid beta 1-42 to 1-40 in the brain and alter synapse connections. A longer study may be warranted in order to determine whether canola oil also eventually impacts tau phosphorylation, since no effects on tau were observed over the six-month exposure period.

“We also want to know whether the negative effects of canola oil are specific for Alzheimer’s disease,” Dr. Praticò added. “There is a chance that the consumption of canola oil could also affect the onset and course of other neurodegenerative diseases or other forms of dementia.”

The research was funded in part by a grant from the Wanda Simone Endowment for Neuroscience.

Related Posts

  • Possible correlation shown between TMI nuclear accident and thyroid cancers
  • Kombucha to kimchi: Which fermented foods are best for your brain?
  • New treatment of acute myeloid leukemia achieves remarkable results in a disease formerly with little hope
  • Natural compound in basil may protect against Alzheimer’s disease pathology

Filed Under: Health Tagged With: Alzheimers, brain, canola, canola oil, disease, memory, oil

Article Sources

  • https://www.templehealth.org/News/CanolaOilLinkedtoWorsenedMemoryandLearningAbilityinAlzheimersDiseaseTempleResearchersReport?id=3247&showBack=true&PageIndex=0&cid=13

About Captain Organic Planet

C.O.P. (Captain Organic Planet) is on a mission to inform anyone with an open mind that our food is far from natural; it is synthetic and fake. I believe our food supply is contributing to most of our diseases. The sad thing is it doesn't end there. Everywhere around us are dangers; in our household, in our water, and in your shampoo. Every aspect of your life is contributing to your health, wellness, sickness and disease. Challenge Conventional Culture. Live Life With An Organic Slant. L.iving O.rganically V.ibrates E.nergy

VIDEOS

View All Videos

Popular

Is Towpath Trail At Cleveland Ohio Steelyard Commons Radioactive From Manhattan Project?

July 27, 2012 By Captain Organic Planet Filed Under: Cancer, Nuclear

14-Year Old Anti-GMO Activist Agitates Monsanto Schill, Kevin O’Leary

November 20, 2013 By Captain Organic Planet Filed Under: GMO's

Vegans At Increased Risk Of Developing Blood Clots And Atherosclerosis

January 5, 2017 By Captain Organic Planet Filed Under: Health

Follow Organic Slant

  • Facebook
  • Twitter
  • YouTube
Organic Slant
Tweets by organicslant

Organic Slant

  • Home
  • About
  • Shop
  • Contact
  • links
  • Advertise
  • Privacy Policy
  • Disclaimer
All Rights Reserved 2018

Organic Slant LLC is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.

  • Home
  • About
  • Shop
  • Contact
  • Articles
  • Videos
  • Cartoons
  • Media
  • Privacy Policy
  • Disclaimer
  • Advertise
  • Media
  • Facebook
  • Twitter
  • YouTube

· Organic Slant All Rights Reserved © 2025 ·