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You are here: Home / Health / Biological Effects Of Popular Artificial Sweetener Sucralose

Biological Effects Of Popular Artificial Sweetener Sucralose

April 10, 2016 by Captain Organic Planet

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The artificial sweetener sucralose is a biologically active compound according to an extensive review published by Taylor & Francis in the recent issue of Journal of Toxicology and Environmental Health, Part B: Critical Reviews.

“Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues” authored by Susan S. Schiffman, PhD, an internationally known sweetener researcher and Kristina I. Rother, MD, MHSc, of the National Institutes of Health (NIH), summarizes the biological properties of sucralose based on hundreds of archival, peer-reviewed scientific journal publications. Some of the biological effects of sucralose described by Schiffman and Rother include:

  • alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,
  • metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,
  • induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal tract to levels that may limit the bioavailability of therapeutic drugs,
  • reduction in the number and balance of beneficial bacteria in the gastrointestinal tract,
  • histopathological findings in gastrointestinal tract including lymphocytic infiltrates into epithelium, epithelial scarring, mild depletion of goblet cells and glandular disorganization in the colon,
  • decomposition and generation of chloropropanols (a potentially toxic class of compounds) during baking, and
  • mutagenic alterations using several types of biological assays

Schiffman and Rother present scientific evidence from numerous laboratories that most of these biological effects occur at sucralose dosages approved for use in the food supply by global health authorities. Overall, the scientific data presented in the review indicate that sucralose possesses many characteristics in common with other organochlorine compounds such as organochlorine drugs, pesticides, and industrial chemicals. The authors conclude that a careful reassessment of safety is needed regarding the use of sucralose by the general population, particularly special populations such as children, elderly, nursing mothers, persons with diabetes, cancer patients, and persons taking multiple medications.

Related Posts

  • You catch (and kill) more flies with this sweetener
  • WHO advises not to use non-sugar sweeteners for weight control
  • Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses
  • How a deadly fungus evades the immune system

Filed Under: Health Tagged With: Splenda, sucralose, sugar, sweetener

Article Sources

  • http://www.tandfonline.com/doi/abs/10.1080/10937404.2013.842523

About Captain Organic Planet

C.O.P. (Captain Organic Planet) is on a mission to inform anyone with an open mind that our food is far from natural; it is synthetic and fake. I believe our food supply is contributing to most of our diseases. The sad thing is it doesn't end there. Everywhere around us are dangers; in our household, in our water, and in your shampoo. Every aspect of your life is contributing to your health, wellness, sickness and disease. Challenge Conventional Culture. Live Life With An Organic Slant. L.iving O.rganically V.ibrates E.nergy

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