Organic Slant

  • Home
  • Shop
  • About
  • Facebook
  • Twitter
  • YouTube
  • Articles
  • Videos
  • Cartoons
  • Music
  • Links
  • Cancer
  • Environment
  • GMO’s
  • Health
  • Monsanto
  • Organic Foods
  • Super Foods
  • Fukushima
You are here: Home / Health / Lab team spins ginger into nanoparticles to heal inflammatory bowel disease

Lab team spins ginger into nanoparticles to heal inflammatory bowel disease

March 28, 2020 by Captain Organic Planet

A recent study by researchers at the Atlanta Veterans Affairs Medical Center took them to a not-so-likely destination: local farmers markets. They went in search of fresh ginger root.

Back at the lab, the scientists turned the ginger into what they are calling GDNPs, or ginger-derived nanoparticles. The process started simply enough, with your basic kitchen blender. But then it involved super-high-speed centrifuging and ultrasonic dispersion of the ginger juice, to break it up into single pellets. (Don’t try this at home!)

The research team, led by Dr. Didier Merlin with VA and the Institute for Biomedical Sciences at Georgia State University, believes the particles may be good medicine for Crohn’s disease and ulcerative colitis, the two main forms of inflammatory bowel disease (IBD).

The particles may also help fight cancer linked to colitis, the scientists believe.

They report their findings, based on experiments with cells and mice, in the September 2016 issue of Biomaterials.

Each ginger-based nanoparticle was about 230 nanometers in diameter. More than 300 of them could fit across the width of a human hair.

Fed to lab mice, the particles appeared to be nontoxic and had significant therapeutic effects:

  • Importantly, they efficiently targeted the colon. They were absorbed mainly by cells in the lining of the intestines, where IBD inflammation occurs.
  • The particles reduced acute colitis and prevented chronic colitis and colitis-associated cancer.
  • They enhanced intestinal repair. Specifically, they boosted the survival and proliferation of the cells that make up the lining of the colon. They also lowered the production of proteins that promote inflammation, and raised the levels of proteins that fight inflammation.

Part of the therapeutic effect, say the researchers, comes from the high levels of lipids — fatty molecules — in the particles, a result of the natural lipids in the ginger plant. One of the lipids is phosphatidic acid, an important building block of cell membranes.

The particles also retained key active constituents found naturally in ginger, such as 6-gingerol and 6-shogaol. Past lab studies have shown the compounds to be active against oxidation, inflammation, and cancer. They are what make standard ginger an effective remedy for nausea and other digestion problems. Traditional cultures have used ginger medicinally for centuries, and health food stores carry ginger-based supplements — such as chews, or the herb mixed with honey in a syrup — as digestive aids.

Delivering these compounds in a nanoparticle, says Merlin’s team, may be a more effective way to target colon tissue than simply providing the herb as a food or supplement.

The idea of fighting IBD with nanoparticles is not new. In recent years, Merlin’s lab and others have explored how to deliver conventional drugs via nanotechnology. Some of this research is promising. The approach may allow low doses of drugs to be delivered only where they are needed — inflamed tissue in the colon — and thus avoid unwanted systemic effects.

The advantage of ginger, say the researchers, is that it’s nontoxic, and could represent a very cost-effective source of medicine.

The group is looking at ginger, and other plants, as potential “nanofactories for the fabrication of medical nanoparticles.”

Merlin and his VA and Georgia State University coauthors elaborated on the idea in a report earlier this year titled “Plant-derived edible nanoparticles as a new therapeutic approach against diseases.” They wrote that plants are a “bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles.”

Related Posts

  • Dietary Ginger May Work Against Cancer Growth
  • Nylon cooking bags, plastic-lined cups can release nanoparticles into liquids
  • Fungi that live in the gut influence health and disease
  • Ginger compounds may be effective in treating asthma symptoms, study suggests

Filed Under: Health Tagged With: ginger, IBD, nanoparticles

Article Sources

  • https://www.research.va.gov/currents/0816-2.cfm
  • Mingzhen Zhang, Emilie Viennois, Meena Prasad, Yunchen Zhang, Lixin Wang, Zhan Zhang, Moon Kwon Han, Bo Xiao, Changlong Xu, Shanthi Srinivasan, Didier Merlin. Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials, 2016; 101: 321 DOI: 10.1016/j.biomaterials.2016.06.018

About Captain Organic Planet

C.O.P. (Captain Organic Planet) is on a mission to inform anyone with an open mind that our food is far from natural; it is synthetic and fake. I believe our food supply is contributing to most of our diseases. The sad thing is it doesn't end there. Everywhere around us are dangers; in our household, in our water, and in your shampoo. Every aspect of your life is contributing to your health, wellness, sickness and disease. Challenge Conventional Culture. Live Life With An Organic Slant. L.iving O.rganically V.ibrates E.nergy

VIDEOS

View All Videos

Popular

Is Towpath Trail At Cleveland Ohio Steelyard Commons Radioactive From Manhattan Project?

July 27, 2012 By Captain Organic Planet Filed Under: Cancer, Nuclear

14-Year Old Anti-GMO Activist Agitates Monsanto Schill, Kevin O’Leary

November 20, 2013 By Captain Organic Planet Filed Under: GMO's

Vegans At Increased Risk Of Developing Blood Clots And Atherosclerosis

January 5, 2017 By Captain Organic Planet Filed Under: Health

Follow Organic Slant

  • Facebook
  • Twitter
  • YouTube
Organic Slant
Tweets by organicslant

Organic Slant

  • Home
  • About
  • Shop
  • Contact
  • links
  • Advertise
  • Privacy Policy
  • Disclaimer
All Rights Reserved 2018

Organic Slant LLC is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.

  • Home
  • About
  • Shop
  • Contact
  • Articles
  • Videos
  • Cartoons
  • Media
  • Privacy Policy
  • Disclaimer
  • Advertise
  • Media
  • Facebook
  • Twitter
  • YouTube

· Organic Slant All Rights Reserved © 2025 ·